Manufactured by: SmithKline Beecham (Polysporin), Technilab (Polytopic), Metapharma (Polytracin)

Active Ingredients: Polymyxin B and Bacitracin

Classification: Topical Antibiotic

Indications: For treating local infections due to susceptible organisms and amenable to treatment, these include infected wounds, burns, and skin grafts, prodermas, folliculitis, infections of external ear.

Contraindications: Hypersensitivity to any of the components.

Precautions: As with any medication containing antibiotic, prolonged use may result in the overgrowth of nonsusceptible organisms, including fungi. Should superinfection occur, the preparation should be discontinued and/or appropriate therapy instituted.

Pregnancy: Polysporing has been used for several years without any evidence of untoward effects in pregnancy. The clinical benefits of treatment must be balanced against any possible, but unknown, hazards to the foetus.

Allergic hypersensitivity following topical administration of polymyxin B and bacitracin zinc is rare but has been reported. Rarely, anaphylactic reactions following topical administration of bacitracin zinc have been reported. Following significant systemic absorption, polymyxin B can intensify and prolong the respiratory depressant effects of neuromuscular blocking agents.

Overdose: If toxic symptoms develop following significant systemic absorption, treatment with Polysporin should be stopped, and general status, renal function and neuromuscular function should be monitored.

Dosage: To be applied to the infected area 2 to 5 times a day..

Supplied as: Each gram contains: polymyxin B sulfate 10,000 units (equivalent to 1 mg polymyxin standard) and bacitracin 500 units. Store at room temperature (15 to 25 degrees Celcius).

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