Manufactured by: SmithKline Beecham
Active Ingredients: Mupirocin
Classification: Topical Antibiotic
Pharmacology: Mupirocin exerts a bactericidal action against sensitive organisms by inhibiting bacterial protien synthesis. It reversibly and specifically binds to bacterial isoleucyl transfer-RNA synthetase.
Indications: For the topical treatment of impetigo caused by sensitive strains of staphylococcus and streptococcus species as well as for other superficially infected dermatoses including lesions which are moist and weeping.
For abrasions, minor cuts and wounds, the use of mupirocin may prevent the development of infection by sensitive Gram-positive organisms.
No cross-resistance has been shown between mupirocin and other commonly used antibiotics.
Contraindications: Individuals with a history of hypersensitivity to mupirocin or to other ointments containing polyethylene glycols.
Warnings: This preparation is not suitable for ophthalmic or intranasal use.
When mupirocin ointment is used on the face, care should be taken to avoid the eyes.
Polyethylene glycol (PEG) can be absorbed from open wounds and damaged skin. It is excreted by the kidneys. As with other PEG based ointments, Mupirocin ointment should not be used in conditions where absorption of large quantities of PEG is possible, especially if there is evidence of moderate or severe renal impairment.
Precautions: Use of topical antibiotics occasionally allows overgrowth of susceptible organisms. If this occurs, or irritation or sensitization develop, treatment should be discontinued and appropriate therapy instituted..
Pregnancy and Lactation: Safety in the treatment of infections during pregnancy has not been established. If administration during pregnancy is considered necessary, its potential benefits should be weighed against the possible hazards to the foetus. Caution should be exercised when mupirocin ointment is administered to nursing mothers.
Adverse Effects: The following local adverse reactions have been reported during treatment with mupirocin: itching, burning, erythema, stinging and dryness. It was not usually necessary to discontinue treatment due to these adverse reactions. Cutaneous sensitization reactions to mupirocin or the ointment base have been reported rarely.
Overdosee: Overdosage has not been known to occur during topical use of mupirocin ointment.
Dosage: A small amount of the ointment should be applied to the affected area 3 times daily for up to 10 days, depending on the response.
Supplied as: Each gram contains: Mupirocin 20 mg (2%) in a bland water-soluble ointment base consisting of polyethylene glycol 400 and polyethylene glycol 3350 (polyethylene glycol ointment, USP). Store at room temperature.
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